...Xing Huang; Lei Wang; Yuan Chen; Xinmin Zheng; Xinghuan Wang Purpose: The study aimed to investigate the expression of thymidine phosphorylase (TP) in renal cell carcinoma (RCC) and its correlation with clinicopathological features and thrombocytosis, and also to determine their prognostic...

... nephrectomy (PN) and thymidine phosphorylase (TP)-expressing macrophages in peritumoral tissue of renal cell carcinoma (RCC). Methods: In 46 patients who underwent radical nephrectomy, we measured TP protein levels in tumor tissue, peritumoral tissue and normal tissue, and conducted immunohistochemical...

... factor, thymidine phosphorylase, tenascin, fibronectin, p53 and bcl-2 to further clarify their implication in tumor stroma vascularization. Nuclear HIF-1α expression in tumor cells was detected in 57.1% of the cases. A trend of correlation of this expression with poorly differentiated tumors was observed...

... was inhibited by 50% as compared with the control value. Thymidine phosphorylase (TP), the enzyme that converts 5′-DFUR into 5-FU and 5-FU into FdUMP, was estimated by ELISA. Results: When the 10 RCC cell lines were divided into the low TP expression group and high TP expression group at 2.0 U/ml protein, TP...

...Tatsuo Iizumi; Kyouichi Hariu; Mika Sato; Satoshi Sato; Hirofumi Shimizu; Hiroshi Tomomasa; Takashi Umeda Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels in transitional cell carcinoma of the bladder resected from 38 patients were examined by ELISA. TP levels in high...