... cell lines. Inhibition of miR-224-5p expression by microRNA inhibitors could inhibit the proliferation, migration, and invasion of ccRCC cells. Besides, it was validated by dual-luciferase assay in which miR-224-5p directly targeted OCLN gene. The expression of OCLN was downregulated in ccRCC cells...

... of RNA molecules that usually do not encode proteins, but regulate gene expression, thereby participating in various cellular processes, such as development, cell differentiation and proliferation, cell cycle, apoptosis, and metabolism [ 7-10 ]. According to the size, ncRNAs can be divided into small...

...Yangle Li; Xiaokun Zhao; Huiting Tang; Zhaohui Zhong; Lei Zhang; Ran Xu; Songchao Li; Yi Wang Objectives: It was the aim of this study to explore the effects of 3-(5′-hydroxymethyl-2′-furyl)-l-benzyl indazole (YC-1) on transcription activity, cell proliferation and apoptosis of hypoxic human...

... cancers is unclear. Here, we investigated the role of protein kinase C (PKC) in ATO-induced apoptosis and inhibition of proliferation in bladder cancer cells. Methods: T24 human bladder carcinoma cells were incubated with different concentrations of ATO in the presence or absence of PMA (PKC activator...