... group, and gastrodin-treated IRI group. Gastrodin or 0.9% saline (300 mg/kg/day) was intragastrically administrated for 8 days before operation. We analyzed renal function and histological change. The malondialdehyde level, antioxidant enzymes’ activities, and markers of inflammation and apoptosis were...

... demonstrate that miR-182 promotes cell apoptosis and I/R injury through directly binding to FoxO3. The present study will provide potential therapeutic targets for renal I/R-induced AKI, and open a new avenue for AKI treatment by manipulating miRNAs levels. [email protected] Acute kidney injury...

...Sheng-Tao Ling; Chun-Lei Deng; Li Huang; Qi-Sheng Yao; Cui Liu; Chuan-Tao Sun; Li Wang; Yong Yang; Xiao-Xin Gong; Cong-Bo Chen Autophagy is an important pro-survival mechanism and closely related to apoptosis. The aim of this study was to investigate whether hydroxychloroquine (HCQ) blocks...

... h of reperfusion, renal function and histologic damage were examined. Myeloperoxidase (MPO) activity assay, in situ apoptosis examination, enzyme-linked immunosorbent assay, immunohistochemical assay, and Western blot were performed as well. Results: Butyrate pretreatment significantly reduced renal...

... genes and 9 miRNAs showed differential expression in # WNT2B cells. Among these were TNFSF10 , a key apoptosis inductor, (0.22fold, p = 0.011) and miR-1246 (36.2fold, p = 0.031). miRNA target prediction indicated TNFSF10 to be regulated by miR-1246. qRT-PCR analysis confirmed differential expression...

... inhibits cell proliferation by decreasing cell cycle and promoting apoptosis in renal cancer cell lines. Mechanistically, LDHA siRNA treatment altered the expression of cell cycle- and apoptosis-related proteins, including p21, cyclin D1, Bcl-2 and Bax. In addition, LDHA siRNA treatment leads to markedly...

... of Jurkat T lymphocytes in vitro. Methods: Exosomes were purified from human kidney adenocarcinoma ACHN cells by sequential centrifugations and ultrafiltrations, and characterized by transmission electron microscopy. The effects of exosomes on the proliferation, cytokine production and apoptosis of Jurkat T...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Apoptosis Renal cell carcinoma Nephrectomy Prognostic factors Urologia Internationalis Original Paper Urol Int 2012;88:263 270 DOI: 10.1159/000334453 Received: June 7...

...Yangle Li; Xiaokun Zhao; Huiting Tang; Zhaohui Zhong; Lei Zhang; Ran Xu; Songchao Li; Yi Wang Objectives: It was the aim of this study to explore the effects of 3-(5′-hydroxymethyl-2′-furyl)-l-benzyl indazole (YC-1) on transcription activity, cell proliferation and apoptosis of hypoxic human...

...In-Youb Chang; Jin-Ho Kim; Kyeong-Han Park; Sang-Pil Yoon Aim: Since DNA damage-related apoptosis is raising concerns regarding abnormal spermatogenesis, we investigated the changes in γ-H2AX during testicular germ cell apoptotic responses in the varicocele model. Materials and Methods: Varicocele...

... shown to induce apoptosis in a variety of cancer cells. We reasoned that combination treatment of renal cell carcinoma (RCC) cells with COX-2 inhibitors and anticancer agents may result in synergistic apoptosis. We examined whether the selective COX-2 inhibitor JTE-522 synergizes with anticancer agents...

...Takeshi Watanabe; Toshihiko Masago; Ikuo Miyagawa Aims: To examine botulinum toxin A (BTX-A)-induced apoptosis in the detrusor muscle in male rats. Methods: The bladder wall and prostate in adult male Sprague-Dawley rats were injected with BTX-A (10 U at each site). Tissues were harvested after 2...

... at 10 –4 M , while the 5HTR1b antagonist induced necrosis at 10 –4 M in all cell lines. Cell cycle alterations were seen in PC3 and DU145 cells under the influence of the 5HTR1a antagonist. Conclusions: Serotonin receptor antagonists and agonists as well as MLT influence viability and apoptosis of PCa...

...Atsushi Sasaki; Seiji Kudoh; Kazuyuki Mori; Nobuyoshi Takahashi; Tadashi Suzuki Because we hypothesized that cell death when bacillus Calmette-Guérin (BCG) was instillated was correlated with apoptosis, cultured urinary bladder carcinoma cells were treated with BCG and examined whether they showed...

...Engin Kandirali; Selahittin Cayan; Abdullah Armagan; Bulent Erol; Ates Kadioglu Aims: Testicular apoptosis has been shown in human specimens, but its correlation with serum gonadotropins and testosterone levels has not been studied. The aim of this study was to evaluate the relationship...

... cancers is unclear. Here, we investigated the role of protein kinase C (PKC) in ATO-induced apoptosis and inhibition of proliferation in bladder cancer cells. Methods: T24 human bladder carcinoma cells were incubated with different concentrations of ATO in the presence or absence of PMA (PKC activator...

.... Apoptosis Verapamil Partial ureteral obstruction Urologia Internationalis Original Paper Urol Int 2008;80:84 89 DOI: 10.1159/000111736 Received: April 12, 2006 Accepted after revision: December 12, 2006 Verapamil Attenuates Renal Tubular Apoptosis in Response to Partial Unilateral Ureteral Obstruction...

... stress as well as germ cell apoptosis indices were assessed 4 and 24 h after detorsion, respectively. Results: The apoptosis indices were significantly higher in group 2 as compared with the control group. Four hours after detorsion, the testicular level of lipid peroxidation was significantly increased...

... administration of N G -nitro- L -arginine methyl ester ( L -NAME), a nitric oxide (NO) synthase (NOS) inhibitor, in preventing testicular ischemic damage and germ cell-specific apoptosis in rats. Materials and Methods: 30 min before ligation of the spermatic vessels, L -NAME was administered intraperitoneally...

...H.U. Schmelz; J. Meiswinkel; M. Port; E.W. Hauck; M.J. Schwerer; W. Weidner; C. Sparwasser; M. Abend Introduction: Apoptosis seems to play an important role in tumorigenesis, prognosis and therapy of testicular tumors. To understand its biological significance, it is importantto quantify the amount...