... cancer (mHSPC) treated with androgen receptor signal inhibitors (ARSIs). Methods: We retrospectively reviewed 82 patients with mHSPC who received upfront ARSI treatment. The primary endpoint was PSA progression-free survival (PFS). Patients whose PSA levels decreased to ≤0.2 ng/mL at 3 months after ARSI...

... of therapeutic pressures. With regard to the fundamental importance of the androgen receptor (AR) in all stages of PCa from tumorigenesis to progression, AR is postulated to have a continued critical role in castration-resistant prostate cancer (CRPC). Suppression of AR signaling mediated by the full-length AR...

... + 3; n = 42 [44.7%]) versus a low-risk group (≤3 + 4; n = 52 [55.3%]). Immunohistochemistry was performed using 15 antibodies with known association to radioresistance in PCA in vitro. ELISA was used for validation of selected markers in serum. Results: Androgen receptor (AR) was overexpressed in most...

...Holger Hans Herman Erb; Peter Sparwasser; Tamara Diehl; Manuela Hemmerlein-Thomas; Igor Tsaur; Eva Jüngel; Ulrich Sommer; Gustavo B. Baretton; Axel Haferkamp; Andreas Neisius; Christian Thomas Introduction: Androgen receptor variant 7 (AR-V7) plays an important role in the progression of castration...

...Filip Poelaert; Candy Kumps; Nicolaas Lumen; Stephanie Verschuere; Louis Libbrecht; Marleen Praet; Sylvie Rottey; Tom Claeys; Piet Ost; Karel Decaestecker; Gert De Meerleer; Charles Van Praet Objectives: To evaluate the androgen receptor (AR) gene copy number in androgen deprivation therapy (ADT...

... cancer patients and cell lines were studied immunohistochemically for c-myc, Pim1, STAT3, pSTAT3-Tyr705, and androgen receptor (AR) expression. The effect of Pim1 on androgen dependence in prostate cancer was studied in transgene cell lines. Results: Pim1 expression was increased in high-grade prostate...

...P.K. Majumder; S.N. Wadhwa; V.L. Kumar Objective: Current reports suggest the presence of androgen receptor (AR) defects in prostate cancer. We have detected the AR mRNA in normal, benign hypertrophied (BPH) and carcinomatous (CaP) prostate tissues and evaluated the difference in the level of AR...

...G. Klötzl; U. Otto; H. Becker; H. Klosterhalfen Twenty-one renal cell carcinomas were analyzed for the presence of androgen progestin and estrogen receptors by agar gel electrophoresis and a dextran-coated charcoal assay. An androgen receptor could be demonstrated in 3 tumors, a progestin...

...Seiichi Saito; Naoto Mikuma; Yosniaki Kumamoto The effect of kallikrein on the Sertoli cells was investigated to determine the rat testicular androgen binding component (ABC = androgen binding protein + androgen receptor) concentration using the dextran-coated charcoal method. The results showed...

...Alex L.G. Schuurmans; Joan Bolt; Eppo Mulder Human prostate tumor cells, LNCaP, contain androgen receptors and respond to androgens with increased growth rate. Although other steroid hormone receptors are not detectable in LNCaP cells, progesterone and estradiol stimulate the growth of these cells...

..., Shimane Medical University, Izumo-shi, Shimane-ken, Japan: bFutami Central Hospital. Miyoshi-shi, Hiroshima-ken, Japan Key Words. Prostatic carcinoma Skin metastascs Androgen receptor Abstract. The 30th case of metastatic skin carcinoma of prostatic origin was presented. The cytosolic R1881 recep­ tor...

.... Prostatic cancer Androphilic protein Androgen receptor R 1881 Endocrine therapy Urol. ini. 38: 25-28 (1983) © 1983 S. Kargcr AG. Basel 0042-1138/83/0381-0025S2.75/0 Histochemical Observation of R 1881-Binding Protein in Human Prostatic Cancer Tsutomu Matsumuraa , Hitoshi Naitoa , Kunio Yamaguchi3...

...Zufeng Wang; Limin Liu; Jianquan Hou; Duangai Wen; Chunyin Yan; Jinxian Pu; Jun Ouyang; Hao Pan Testosterone signaling is widely considered to be mediated through the transcription-regulating intracellular androgen receptor (iAR). In the human prostate cancer cell line LNCaP we demonstrated...

... serum and tissue testosterone levels. Real-time quantitative polymerase chain reaction (PCR) was used to measure the levels of androgen receptor (AR) and estrogen receptor-β (ERβ) mRNA of the ventral prostate. Histological compositions were analyzed by quantitative morphometry. Immunohistochemical...

...Kelly J. Cude; Jeffrey S. Montgomery; Douglas K. Price; Shannon C. Dixon; Randall L. Kincaid; Karl F. Kovacs; David J. Venzon; David J. Liewehr; Margaret E. Johnson; Eddie Reed; William D. Figg The androgen receptor plays a major role in the development and function of normal and malignant prostate...

... receptor expression in LNCaP-abl cells was 4-fold higher than that in parental LNCaP cells (4.7 vs. 1.2 fmol/µg protein). Androgen receptor content in LNCaP-R cells was 1.8 fmol/µg protein and in LNCaP-RA cells 1.0 fmol/µg protein. The basal androgen receptor activity was 30-fold higher in LNCaP-abl cells...

... immunohistochemically for prostate-specific antigen and the androgen receptors. All metastases including those in the brain expressed neither androgen receptor nor prostate-specific antigen at the protein and mRNA levels. The tumor, which did not respond to the anti-androgen therapy, had an aggressive course...