a Hematoxylin and eosin staining reveals highly atypical tumor cells with irregular glandular structures and prominent nucleoli resembling nuclear inclusions. b FH staining demonstrates a loss of FH protein in the tumor cells, with proximal tubules serving as the positive control for evaluation. c Hematoxylin and eosin stain illustrates the spatial relationship between the tumor and stroma (dotted lines). d PD-L1 staining indicates that PD-L1 is expressed on tumor cells. e, f CD4 and CD8-positive lymphocyte infiltrations are observed, predominantly in the stroma, with minimal infiltration within the tumor. FH: polyclonal rabbit anti-FH antibody (Sigma-Aldrich, HPA025770), CD8: monoclonal mouse anti-CD8 antibody, clone C8/144B (Histofine, Nichirei Biosciences), PD-L1: monoclonal mouse anti-PD-L1 antibody, clone 22C3 (PharmDx, Dako).
Fig. 2.

a Hematoxylin and eosin staining reveals highly atypical tumor cells with irregular glandular structures and prominent nucleoli resembling nuclear inclusions. b FH staining demonstrates a loss of FH protein in the tumor cells, with proximal tubules serving as the positive control for evaluation. c Hematoxylin and eosin stain illustrates the spatial relationship between the tumor and stroma (dotted lines). d PD-L1 staining indicates that PD-L1 is expressed on tumor cells. e, f CD4 and CD8-positive lymphocyte infiltrations are observed, predominantly in the stroma, with minimal infiltration within the tumor. FH: polyclonal rabbit anti-FH antibody (Sigma-Aldrich, HPA025770), CD8: monoclonal mouse anti-CD8 antibody, clone C8/144B (Histofine, Nichirei Biosciences), PD-L1: monoclonal mouse anti-PD-L1 antibody, clone 22C3 (PharmDx, Dako).

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal