IPSS reduction at least 12 months after the second-line therapy. Presents the IPSS reduction after various the second-line therapies following failure. This analysis included patients who required further intervention due to the initial PAE not achieving the desired outcomes. The graph shows a significant improvement in IPSS following ablative interventions (p < 0.0001; 95% CI: 12.75, 18.74). Error Bars: represent the SD, indicating the variability in IPSS reduction among patients undergoing each type of the second-line therapy.