... previous lines of therapy. During the study period, 49.0% (50/102) of patients deceased. Additional MTB-based treatment recommendations were achieved in a majority of 68.6% (70/102) of patients, with a recommendation for targeted therapy in 64.3% (45/70) of these patients. Only 6.7% (3/45) of patients...

... trials demonstrated efficacy and safety of molecular-targeted therapy, including tyrosine kinase inhibitors (TKIs) [ 1‒5 ]. Based on these evidences, TKIs had played a central role in systemic therapy for mRCC. Currently, although the guidelines recommend immune checkpoint inhibitors (ICIs) as first-line...

... will report possible strategies and new clinical approaches that address the CSC-based concept of tumorigenesis in PCa. Prostate cancer Targeted therapy Cancer stem cells [email protected] 12 10 2016 13 12 2016 1 2 2017 Prostate cancers (PCa) are highly heterogeneous...

... in late-onset hypogonadism (LOH). The aim of this study was to investigate the prevalence of LOH in patients with localized RCC (loRCC) and metastatic RCC (mRCC) disease under targeted therapy (TT) and compare the results to findings of epidemiologic studies. Methods: A total of 51 mRCC patients under TT...

...Bernhard Ralla; Barbara Erber; Irena Goranova; Amelie Klooker; Andreas Maxeiner; Stefan Hinz; Carsten Kempkensteffen; Ahmed Magheli; Kurt Miller; Jonas Busch Objectives: Current evidence of sequence-targeted therapy (TT) for patients with metastatic renal cell carcinoma (mRCC) beyond fourth-line...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Renal cell carcinoma Relative survival SEER Targeted therapy Renal cell carcinoma (RCC) accounts for approximately 2-3% of all malignancies with 64,770 new cases and 13,570...

... targeted therapies in bladder and testicular cancers are still more or less limited to single-case experiences. The great theoretical potential and the multitude of possible targets and drug combinations, however, support further research into this exciting field of medical treatment of urologic...