... to be a neurobiological dysfunction with genetic vulnerability and is related to disturbances of central serotonin (5-hydroxytryptamine, 5-HT) neurotransmission and 5-HT receptor function. Aim: To investigate the relationship between the C–759T and G–697C polymorphisms of the 5-HT 2C receptor and LPE. Methods...

...I. Pirozhok; A. Meye; O.W. Hakenberg; S. Fuessel; M.P. Wirth Objectives: To investigate the effects of serotonin and melatonin (MLT) on the regulation of malignant growth and the activity of serotonin receptors (5HTR1a/-1b) in prostate cancer (PCa) cell lines. Materials and Methods: In four PCa...

...Sedef Gidener; Ziya Kirkali; Hülya Güven The influence of serotonin (5-hydroxytryptamine, 5-HT) on human ureteral smooth muscle was explored in a series of in vitro experiments. 5-HT evoked a dose-dependent contraction of the ureter. The effect of 5-HT was unaltered by blockade of 5HT 3 and 5HT 4...

...Ryuji Sakakibara; Takashi Ito; Tomoyuki Uchiyama; Yusuke Awa; Chiharu Yamaguchi; Takamichi Hattori Aims: To determine the effects of milnacipran hydrochloride, a serotonin-norepinephrine reuptake inhibitor (SNRI), or paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on overactive...

...David H.W. Lau; Cecil S. Thompson; Faiz H. Mumtaz; Robert J. Morgan; Dimitri P. Mikhailidis Introduction: Serotonin (5-hydroxytryptamine; 5-HT) can cause contraction in cavernosal smooth muscle. We further evaluated this effect of 5-HT. Methods: Organ bath studies were used. Results: 5-HT induced...

...Hyung Jee Kim; Gilho Lee; Dong Hee Kim; Suk Jae Lee; Duck Ki Yoon; Jae Heung Cho Introduction: The purpose of this study is to investigate in vitro the effects of serotonin on the rat detrusor. In particular, it examines which drugs inhibit the serotonin-induced detrusor contractions. Materials...