... highlights a patient diagnosed with seminoma associated with multiple abnormalities and explores the genetic basis behind these manifestations. Case Presentation: A 22-year-old East Asian male presented with left-sided varicocele and recent onset testicular pain. Clinical examination and imaging revealed...

... of 55 years, all of whom had primary seminoma and six had previous groin surgery. The relative frequency of I/M is 1.1% and 8.3% in the GCT patient cohort and the metastasized seminoma subgroup, respectively. All patients were cured, six underwent surgery and additional chemotherapy, and two received...

... recommendations separately for patients with metastatic seminoma and non-seminomatous GCT (stages IIA/B and IIC/III), for restaging and treatment of residual masses, and for relapsed and refractory disease stages. The recommendations also cover extragonadal and sex cord/stromal tumours, the management of follow...

...Serkan Akan; Caner Ediz; Hasan Hüseyin Tavukcu; Alpaslan Ozgun; Omer Yilmaz Background: The aim of this study was to examine clinical/pathological characteristics, prognosis and tendency to metastasis of mixed germ cell tumours (MGCTs) that contain a seminoma component. Methods: A total of 111 MGCT...

..., there is only limited information regarding the velocity of decline of serum levels in response to treatment. Patients and Methods: Twenty-four patients with testicular GCT (20 seminoma, 4 nonseminoma, median age 40 years) with clinical stage 1 had measurements of serum levels of miR-371a-3p preoperatively...

...)-stages and serum biomarker expression. The results were analysed descriptively and compared with the literature. Results: Median age was 36 years and 60.2% had seminoma. Βeta-human chorionic gonadotropin was expressed in 37.9% and alpha Fetoprotein in 25.6%. CS1 presenting stage was 66.6% of all GCT...

...Klaus-Peter Dieckmann; Petra Anheuser; Hanna Simonsen; Doris Höflmayer Background: Pure testicular seminoma does not express alpha fetoprotein (AFP). However, seminoma patients with mildly elevated serum AFP levels are increasingly reported. As this finding may prompt unwarranted treatment measures...

... 1 (CS1) seminoma. Patients and Methods: During 2008-2013, 1,050 patients with seminoma CS1 were prospectively registered with regard to assessing management modality (radiotherapy, carboplatin, surveillance). Associations with tumor size, rete testis invasion, age, year of diagnosis, type...

.... Results: 21 evaluable patients were identified (14 non-seminomatous germ cell tumours, 7 seminomas). 16 patients underwent standard orchidectomy within 12 months of commencing chemotherapy and 5 patients underwent significantly delayed orchidectomy (19-68 months, mean 45.1 months). Orchidectomy...

... of ultrasound findings in benign versus malignant testicular lesions. Materials and Methods: The medical records and ultrasound images of 107 patients with testicular tumor were reviewed. Demographic and clinical characteristics and ultrasound findings of patients with seminoma were compared to those...

... in advanced seminoma is controversial. It has been proposed that fluorodeoxyglucose-positron emission tomography (FDG-PET) can be used as a follow-up. In this study we investigated FDG-PET as a follow-up tool in advanced seminoma patients treated previously with chemotherapy or radiotherapy. Thirty-seven...

... Seminoma Seminomatous testicular cancer Testicular cancer, recurrence Testicular cancer, survival 8 12 2010 30 05 2011 26 8 2011 © 2011 S. Karger AG, Basel 2011 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...

...Markus Letsch; Martin Spahn; Matthias Beissert; Max S. Topp; Elmar W. Gerharz; Hubertus Riedmiller Ten years after his brother had been treated for seminoma, a 36-year-old male presented with a giant exulcerating mass involving the right testis and both inguinal regions. Subsequent biopsy revealed...

...W. Bohle; U. Ruether; J. Rassweiler; C. Nunnensiek; F. Eisenberger; P. Jipp Single-agent carboplatin chemotherapy has recently been introduced into the therapy of limited seminoma. Because of poor compliance due to Down’s syndrome we successfully treated a 32-year-old man with relapsed stage-IIIB...

...K. Koshida; T. Uchibayashi; H. Hisazumi Characteristics of placental-like alkaline phosphatase (PLAP-like enzyme) in seminoma was studied. By use of lectin affinity chromatography PLAP-like enzyme in seminoma revealed extra sugar chains compared to placental alkaline phosphatase (PLAP), indicating...

...Hajime Yamamoto; Tadao Uchibayashi; Kiyoshi Koshida; Kazuyuki Hirano; Haruo Hisazumi An immunohistopathological study using monoclonal antibodies for alkaline phosphatases demonstrated placental alkaline phosphatase (PLAP)-like substance in the tumor cells of 11 pure seminomas, 1 seminoma...

...R. Ravi; A. Vasanthan Four patients with advanced testicular seminoma and <S01_MathematicalPi1>> </S01_MathematicalPi1>3 cm postchemotherapy residual retroperitoneal masses underwent retroperitoneal lymph node dissection (RPLND) followed by intraoperative irradiation (IORT) to a dose...

...Hartmut E.H. Wegner; Barbara Fleige; Klaus-Peter Dieckmann This is the first report of a desmoid tumor 19 years after radiation therapy for seminoma of the testis at the age of 40. It stresses the need to include the desmoid tumor in the differential diagnosis of an intra-abdominal tumor after...

... the type of tumor (seminoma versus nonseminomatous tumor) was correct in 70%. The typical sonography of the seminoma comprises homogeneous, hypoechogenic and sharply delineated masses, but nonseminomatous tumors are inhomogeneous, hypoechogenic, normoechogenic and hyperechogenic masses with cysts...

...J. Steffens; W. Friedmann; R. Nagel 38 pure and 11 mixed seminomas were studied with the peroxidase-anti-peroxidase method for the presence of chorionic gonadotropin (Β-HCG) and pregnancy-specific Β 1 -glycoprotein (SP 1 ). HCG was found in 8 of 49 cases, SP 1 in 5 of 49 cases in syncytial...