...Stefan Propping; Melanie Roedel; Manfred P. Wirth; Ursula Ravens Objectives: The mucosa of human detrusor strips impairs catecholamine-induced relaxation. In order to elucidate which signal transduction pathways are involved in this cross talk between the mucosa and detrusor, we have studied...

...Stefan Propping; Manja Newe; Kristina Lorenz; Manfred P. Wirth; Ursula Ravens Aims: To study the β-adrenoceptor subtypes involved in the relaxation responses to (-)-isoprenaline in carbachol-pre-contracted (CCh) mouse detrusor muscle with intact and denuded mucosa. Methods: Isolated muscle strips...

... responses in the dome preparations; relaxation at 10 ––8 g/ml and contractions at 10 ––7 –10 ––6 g/ml. In the trigone preparations, 10 ––8 –10 ––6 g PGE 1 /ml caused dose-dependent contractions. 10 ––8 –10 ––6 g PGE 2 /ml and 10 ––7 –10 ––6 g PGF 2Α /ml induced dose-dependent contractions of the dome...

.../medium ratio of about 3 was found at an exposure time of 60 min. The accumulation of the drug was reversible after washing in drug-free solution, indicated by the loss of radioactivity increasing with longer washing times. The results show that pitofenone has a direct relaxant effect on smooth muscle...