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Keywords: MicroRNA
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Journal Articles

Metformin Regulates the miR-205/VEGFA Axis in Renal Cell Carcinoma Cells: Exploring a Clinical Synergism with Tyrosine Kinase Inhibitors

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Markus Krebs, Mischa J. Kotlyar, Julian Fahl, Sudha Janaki Raman, Florian Röhrig, André Marquardt, Hubert Kübler, Burkhard Kneitz, Almut Schulze, Charis Kalogirou
Journal: Urologia Internationalis
Urol Int (2024) 108 (1): 49–59.
https://doi.org/10.1159/000535025
Published Online: 30 November 2023
... cell renal cell carcinoma (ccRCC) patients. Functionally, MF induces miR-205, a microRNA serving as a tumor suppressor in several cancers. Methods: Real-time quantitative PCR, viability assays, and Western blotting analyzed MF and SUT/AX effects in RCC4 and 786-O cells. A tetracycline-inducible...
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Journal Articles

MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid

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Klaus-Peter Dieckmann, Meike Spiekermann, Thomas Balks, Raphael Ikogho, Petra Anheuser, Werner Wosniok, Thomas Loening, Jörn Bullerdiek, Gazanfer Belge
Journal: Urologia Internationalis
Urol Int (2016) 97 (1): 76–83.
https://doi.org/10.1159/000444303
Published Online: 19 March 2016
...Klaus-Peter Dieckmann; Meike Spiekermann; Thomas Balks; Raphael Ikogho; Petra Anheuser; Werner Wosniok; Thomas Loening; Jörn Bullerdiek; Gazanfer Belge Background: microRNAs (miRs)-371-3 are suggested to be novel biomarkers of germ cell tumors (GCTs), but their specificity is unresolved. We aimed...
View article titled, MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid
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Journal Articles

Metformin-Derived Growth Inhibition in Renal Cell Carcinoma Depends on miR-21-Mediated PTEN Expression

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Charis Kalogirou, Daniel Schäfer, Markus Krebs, Florian Kurz, Andreas Schneider, Hubertus Riedmiller, Burkhard Kneitz, Daniel Vergho
Journal: Urologia Internationalis
Urol Int (2016) 96 (1): 106–115.
https://doi.org/10.1159/000441011
Published Online: 24 October 2015
..., instructions or products referred to in the content or advertisements. microRNA miRNA miR-21 PTEN Metformin Renal cell carcinoma Kidney cancer Biomarker Modified cell metabolism is a vital component for cancer cells. MF is an anti-diabetic drug which - besides improving glycaemic control...
View article titled, Metformin-Derived Growth Inhibition in Renal Cell Carcinoma Depends on miR-21-Mediated PTEN Expression
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