... bladder transitional carcinoma cells (BTCC), mediated by hypoxia-inducible factor 1α (HIF-1α). Methods: BTCC cell line T24 cells were incubated under normoxic or hypoxic conditions, adding different doses of YC-1. The protein expression of HIF-1α and HIF-1α-mediated genes was detected by Western blotting...

.... Further, hypoxia-inducible factor 1α (HIF-1α) constitutes a nuclear transcription factor normally upregulated under hypoxic conditions. We hypothesized that HIF-1α is expressed in the hydronephrotic renal pelvis, as a result of tissue hypoxia. Patients and Methods: Renal pelvis tissue specimens were...