... rewarding as intrinsic cardiovascular activites of these compounds impeded sufficient dosage. Renal cell carcinomas are considered to be good models for the evaluation of this new therapeutic concept. In 35 primary human renal cell carcinomas, the potency of 7 different calcium antagonists in combination...

...S. Naito; J. Kumazawa; A.C. von Eschenbach; I.J. Fidler The demonstration that cancers are biologically heterogeneous has a far-reaching implication for therapy. We reviewed recent data from our laboratories that deal with metastatic heterogeneity of human renal cell carcinoma (HRCC...

...Wolfgang Roessler; Beate Rothgangel; Ferdinand Hofstaedter; Wolf F. Wieland The effects of high-energy shock waves (HESW) on the human renal cell carcinoma were examined. The kidneys were available from 32 patients treated by radical nephrectomy due to renal cell carcinoma. Immediately after...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Human renal cell carcinoma P-170 glycoprotein...

...W. de Riese; B. Aeikens; G. Lenis; E. Schindler We present a new modified in vitro culture assay for primary human renal cell carcinoma similar to the ‘soft agar clonogenic assay’. However, the carrying out and expense of metrology are more simplified, allowing tumor-specific chemotherapeutic drug...

...H. Bojar; K. Maar; W. Staib In an attempt to elevate the concentration of progestin-binding components in human renal cell carcinoma, 24 patients were treated prior to tumour nephrectomy with various doses of oestrogens, potent inducers of progestin receptor synthesis. Low-dose oestrogen treatment...

...H. Bojar; K. Maar; W. Staib Based on the potential progestin sensitivity of the growth of human renal cell carcinoma, tumour tissue from 88 patients was analysed for progestin receptors. With the dextran-coated charcoal assay, cytoplasmic components which bound the potent progestin R 5020...

...H. Bojar; K. Maar; W. Staib In order to investigate whether progestins may trigger tumour regression by a mechanism involving the glucocorticoid receptor, human renal cell carcinomas obtained from 15 patients were analysed for cytoplasmic glucocorticoid-binding components, using [ 3 H...

...H. Bojar; K. Maar; W. Staib Cytosol preparations obtained from 9 different human renal cell carcinomas were investigated for the eventual presence of progestin-binding inhibitors which might offer an explanation for the previous failure to demonstrate high receptor levels in the tumour tissue...

...H. Bojar; K. Maar; W. Staib The binding of methyltrienolone (R 1881, 17β-hydroxy-17α-methyl-estra-4,9,11-trien-3-one), a highly active synthetic androgen, by cytosol preparations from human renal cell carcinoma was investigated. High-affinity, low-capacity binding components for R 1881 were...