... tumoral nuclei presenting with at least 1 AR gene and 1 X centromere probe. AR gene amplification was defined as >20% of cells with ≥2 AR signals per X. Chromosome X polysomy was defined as ≥10% of cells with >1 X chromosome. The intraclass correlation coefficient (ICC) for FISH observations...

...Jelena Milašin; Sava Micic A cytogenetically detectable form of gene amplification, presumably oncogene amplification, double minute chromosomes, has been found in 11 out of 45 specimens (24%) of moderately and poorly differentiated, deeply infiltrating transitional cell carcinoma of the bladder...