.... While AR gene amplification was observed in 25% of patients in the castration-refractory group, it was not present in the ADT treatment-naïve group (p = 0.012). Increased AR gene copy number in >20% of cells was more common in castration-refractory patients (5/8 vs. 4/62, p < 0.001); also ≥15...

...Jelena Milašin; Sava Micic A cytogenetically detectable form of gene amplification, presumably oncogene amplification, double minute chromosomes, has been found in 11 out of 45 specimens (24%) of moderately and poorly differentiated, deeply infiltrating transitional cell carcinoma of the bladder...