... drugs. The aim of our study was to evaluate intravesical gemcitabine + docetaxel (Gem/Doce) versus BCG with respect to quality of life (QOL), safety, and efficacy in NMIBC. Methods: A total of 60 patients with NMIBC were evaluated between July 2019 and December 2020 in a prospective manner. The sample...

...%) participants were stated to regularly use NAC and AC respectively. The number of participants who were stated to use NAC and AC regularly was not associated with the type of institution (academic vs. nonacademic), number of hospital beds, and number of cystectomies performed annually. Gemcitabine/cisplatin...

..., but developed pulmonary metastatic disease 7 months postoperatively. Six cycles of gemcitabine/cisplatin combination chemotherapy with an addition of gefitinib as daily oral medication were administered within a randomized phase II clinical trial; this resulted in complete remission of the pulmonary metastases...

.... Methods: Chemotherapy-naïve patients with advanced or metastatic urothelial carcinoma were randomized 1:1:1 to receive six cycles of chemotherapy (gemcitabine 1,250 mg/m 2 on days 1 and 8, and cisplatin 70 mg/m 2 on day 1 of every cycle) concomitantly with gefitinib 250 mg/day (arm A); or with sequential...

...Maurizio A. Brausi; Paolo Gontero; Vincenzo Altieri; Renzo Colombo; Ilaria Conti; Aldo Vittorio Bono Purpose: The purpose of this phase II study was to evaluate whether low-risk non-muscle-invasive bladder cancer can be ablated with intravesical gemcitabine in a marker lesion study. Patients...

...Hiroki Ide; Atsuko Satou; Katsura Hoshino; Yota Yasumizu; Yasumitsu Uchida; Yuji Tasaka; Takeshi Masuda This is the first report of urothelial carcinoma (UC) in a hemodialysis (HD) patient treated with almost the same doses of gemcitabine and paclitaxel (GP) as those administered to patients...

...Massimo Porena; Michele Del Zingaro; Massimo Lazzeri; Luigi Mearini; Antonella Giannantoni; Vittorio Bini; Elisabetta Costantini Objective: To evaluate the safety, tolerability and efficacy of adjuvant intravesical gemcitabine versus bacillus Calmette-Guérin (BCG) in the treatment of high-risk...

...Mauro Gacci; Riccardo Bartoletti; Tommaso Cai; Stefano Nerozzi; Novello Pinzi; Fabrizio Repetti; Fabrizio Viggiani; Paolo Ghezzi; Gabriella Nesi; Marco Carini Objective: The aim of this pilot study is to analyze the safety and short-term efficacy of gemcitabine (GEM) as salvage intravesical therapy...

...P. Bassi; V. De Marco; I.M. Tavolini; F. Longo; F. Pinto; M. Zucchetti; E. Crucitta; L. Marini; F. dal Moro Introduction: Gemcitabine, a chemotherapeutic agent, has been shown to be active against transitional cell cancer of the bladder. The aim of the study was to determine the pharmacokinetic...

...Enrico Meliani; Alberto Lapini; Sergio Serni; Cristoforo Corvino; Marco Carini Objective: To evaluate the toxicity of gemcitabine and cisplatin combination therapy in adjuvant regimen after radical cystectomy for muscle invasive bladder cancer. Patients and Methods: Forty patients underwent radical...