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Keywords: Druggable mutations
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Journal Articles
Targeted Therapy in Patients with Metastatic Male Germ Cell Tumors
Available to PurchaseSubject Area:
Further Areas
Journal:
Urologia Internationalis
Urol Int (2021) 105 (7-8): 720–723.
Published Online: 17 March 2021
... to identify druggable mutations in metastatic lesions of 3 patients with mGCT. Mutational analysis revealed KIT D820G, TP53, and NPM1 mutations as well as mismatch repair deficiency with loss of MSH2 and MSH6 proteins so that targeted therapy with sunitinib ( n = 2) or pembrolizumab ( n = 1) was initiated...
