Introduction: Donation after cardiac death (DCD) began in 2011 after the program hosted by the First Affiliated Hospital of Sun Yat-sen University in China. The aim of this study is to report on our experience regarding the method of preserving donated kidneys for DCD kidney transplantation. Material and Methods: A total of 37 donors and 73 primary kidney transplant recipients during the period 2011-2014 in the Urology Center of the First Hospital of Jilin University were enrolled in the study. Recipients were assigned to traditional static cold storage (SCS) group and hypothermic machine perfusion (HMP) group based on the preservation environment of donated kidneys after organ harvest. Clinical data were collected for each group. Result: The HMP group had a lower rate of delayed graft function (DGF), better postoperative recovery and kidney function compared with that of SCS group. There is no significant difference in postoperative rejection incidence between the 2 groups. Conclusions: DCD kidneys stored by hypothermic machine contribute to a lower rate of DGF and promoted the rehabilitation progress.

1.
Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, Held PJ, Port FK: Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999;341:1725-1730.
2.
Huang J, Millis JM, Mao Y, Millis MA, Sang X, Zhong S: A pilot programme of organ donation after cardiac death in China. Lancet 2012;379:862-865.
3.
Lindell SL, Muir H, Brassil J, Mangino MJ: Hypothermic machine perfusion preservation of the DCD kidney: machine effects. J Transplant 2013;2013:802618.
4.
Li Y, Li J, Fu Q, Deng R, Liu L, Yuan X, Wang C: En bloc dual kidney transplantation from pediatric donors after cardiac death: initial experience in China. Urol Int 2014;93:482-486.
5.
Moers C, Leuvenink HG, Ploeg RJ: Non-heart beating organ donation: overview and future perspectives. Transpl Int 2007;20:567-575.
6.
Bellingham JM, Santhanakrishnan C, Neidlinger N, Wai P, Kim J, Niederhaus S, Leverson GE, Fernandez LA, Foley DP, Mezrich JD, et al: Donation after cardiac death: a 29-year experience. Surgery 2011;150:692-702.
7.
Friedersdorff F, Roller C, Manus P, Cash H, Stier K, Schmidt D, Budde K, Kemkensteffen C, Busch J, Fuller TF, et al: Fate of finally transplanted deceased donor kidneys initially rejected at other kidney transplantation centers. Urol Int 2014;93:474-481.
8.
Kosieradzki M, Rowiński W: Ischemia/reperfusion injury in kidney transplantation: mechanisms and prevention. Transplant Proc 2008;40:3279-3288.
9.
Bon D, Chatauret N, Giraud S, Thuillier R, Favreau F, Hauet T: New strategies to optimize kidney recovery and preservation in transplantation. Nat Rev Nephrol 2012;8:339-347.
10.
Cannon RM, Brock GN, Garrison RN, Smith JW, Marvin MR, Franklin GA: To pump or not to pump: a comparison of machine perfusion vs cold storage for deceased donor kidney transplantation. J Am Coll Surg 2013;216:625-633; discussion 633-634.
11.
Perico N, Cattaneo D, Sayegh MH, Remuzzi G: Delayed graft function in kidney transplantation. Lancet 2004;364:1814-1827.
12.
Moers C, Smits JM, Maathuis MH, Treckmann J, van Gelder F, Napieralski BP, van Kasterop-Kutz M, van der Heide JJ, Squifflet JP, van Heurn E, et al: Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009;360:7-19.
13.
Lindell SL, Compagnon P, Mangino MJ, Southard JH: UW solution for hypothermic machine perfusion of warm ischemic kidneys. Transplantation 2005;79:1358-1361.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.