Objective: The efficacy of skin icing to reduce the pain of goserelin injection has been reported. We investigated the optimal icing time with a frozen gel pack and its effectiveness. Methods: Abdominal skin temperatures of 49 healthy volunteers were measured after application of the frozen gel pack for 10, 15 and 30 s, and it was decided that a 15-second icing was adequate. For 55 consecutive patients who received goserelin (10.8 mg) injection, pain was evaluated employing a visual analog scale (VAS). The first injection was administered routinely. A second injection was administered after skin icing in 27 of 55 patients who wanted to try icing. At the time of the third injection, all patient decided whether they were to receive icing or the routine method. Results: After icing, VAS scores decreased in 20 of 27 patients. At the third injection, 18 patients requested icing. Conclusion: When a patient complains of injection pain, the icing method should be considered for pain reduction.

1.
Matsuda T, Marugame T, Kamo K, et al; Japan Cancer Surveillance Research Group: Cancer incidence and incidence rates in Japan in 2005: based on data from 12 population-based cancer registries in the Monitoring of Cancer Incidence in Japan (MCIJ) project. Jpn J Clin Oncol 2011;41:139-147.
2.
Akaza H: Future prospects for luteinizing hormone-releasing hormone analogues in prostate cancer treatment. Pharmacology 2010;85:110-120.
3.
Williams G, Lindsay S, Bowsher WG: Randomized crossover trial to assess the tolerability of LHRH analogue administration. Prostate Cancer Prostatic Dis 2003;6:187-189.
4.
Montgomery BSI, Borwell JP, Higgins DM: Does needle size matter? Patient experience of luteinizing hormone-releasing hormone analogue injection. Prostate Cancer Prostatic Dis 2005;8:66-68.
5.
Bechara FG, Sand M, Altmeyer P, et al: Skin cooling for botulinum toxin A injection in patients with focal axillary hyperhidrosis: a prospective, randomized, controlled study. Ann Plast Surg 2007;58:299-302.
6.
Daimon S, Seto T, Hoshiba N, et al: Effect of local cooling of the skin to control pain during arteriovenous fistula cannulation in hemodialysis patients. Nihon Toseki Igakkai Zasshi 2010;43:429-432.
7.
Raulin C, Greve B, Hammes S: Cold air in laser therapy: first experiences with a new cooling system. Laser Surg Med 2000;27:1019-1026.
8.
Ernst E, Fialka V: Ice freezes pain? A review of the clinical effectiveness of analgesic cold therapy. J Pain Symptom Manage 1994;9:56-59.
9.
de Jong RH, Hershey WN, Wagman IH: Nerve conduction velocity during hypothermia in man. Anesthesiology 1966;27:805-810.
10.
Fukai K, Ohnakado H: Experimental study of nursing analgesic techniques for reduction of pain in the injected skin - how does pain threshold of skin in dorsum of hand change during rubbing, cold or hot compress? Kango Kenkyu 1992;15:47-55.
11.
Kinoshita H, Kawa G, Hiura Y, et al: Effectiveness of skin icing in reducing pain associated with goserelin injection. Int J Clin Oncol 2010;15:472-475.
12.
Ikeda K, Ogawa Y, Nagahara H, et al: Evaluation of pain reduction upon injecting goserelin acetate using an ice pack. Jpn J Cancer Chemother 2010;37:291-293.
13.
Nukui A, Morita T: Effect of local cooling at injection site of goserelin acetate for pain relief. Jpn J Cancer Chemother 2011;38:967-972.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.