Introduction: The purpose of this study was to evaluate the prevalence of simple renal cysts (SRCs) in patients with renal neoplasia. Patients and Methods: The study population consisted of 482 patients who underwent partial or radical nephrectomy for kidney tumour between 2006 and 2010. Prevalence of cysts was evaluated retrospectively on a preoperative CT or MRI scan. Results: SRCs are more prevalent in patients with papillary renal cell cancer (RCC) than patients with clear cell RCC. All obese (BMI ≥30) patients in our study population had SRCs. Conclusions: This is the first study to show an association between SRCs and papillary RCC.

1.
Bonsib SM: Renal cystic diseases and renal neoplasms: a mini-review. Clin J Am Soc Nephrol 2009;4:1998-2007.
2.
Kremer H, Dobrinski W, Schreiber MA, Zollner N: Sonography of the abdomen as a screening method (in German). Ultraschall Med 1984;5:272-276.
3.
Bisceglia M, Galliani CA, Senger C, Stallone C, Sessa A: Renal cystic diseases: a review. Adv Anat Pathol 2006;13:26-56.
4.
Hajj P, Ferlicot S, Massoud W, Awad A, Hammoudi Y, Charpentier B, et al: Prevalence of renal cell carcinoma in patients with autosomal dominant polycystic kidney disease and chronic renal failure. Urology 2009;74:631-634.
5.
Zou G: A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol 2004;159:702-706.
6.
R Development Core Team. R: A language and environment for statistical computing. 2005. Available at: http://www.R-project.org (accessed October 29, 2008).
7.
Ljungberg B, Holmberg G, Sjodin JG, Hietala SO, Stenling R: Renal cell carcinoma in a renal cyst: a case report and review of the literature. J Urol 1990;143:797-799.
8.
Lin CJ, Chen YC, Chen HH, Wu CJ, Hsu JM: Renal cell carcinoma presenting as a huge simple renal cyst. Med Oncol 2008;25:104-106.
9.
Schwarz A, Vatandaslar S, Merkel S, Haller H: Renal cell carcinoma in transplant recipients with acquired cystic kidney disease. Clin J Am Soc Nephrol 2007;2:750-756.
10.
Peruzzi B, Bottaro DP: Beta-catenin signaling: linking renal cell carcinoma and polycystic kidney disease. Cell Cycle 2006;5:2839-2841.
11.
Montani M, Heinimann K, von Teichman A, Rudolph T, Perren A, Moch H: VHL-gene deletion in single renal tubular epithelial cells and renal tubular cysts: further evidence for a cyst-dependent progression pathway of clear cell renal carcinoma in von Hippel-Lindau disease. Am J Surg Pathol 2010;34:806-815.
12.
Wiesener MS, Maxwell PH, Eckardt KU: Novel insights into the role of the tumour suppressor von Hippel-Lindau in cellular differentiation, ciliary biology, and cyst repression. J Mol Med (Berl) 2009;87:871-877.
13.
Surendran K, Selassie M, Liapis H, Krigman H, Kopan R: Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol 2010;21:819-832.
14.
McGuire BB, Fitzpatrick JM: The diagnosis and management of complex renal cysts. Curr Opin Urol 2010;20:349-354.
15.
Brannon AR, Haake SM, Hacker KE, et al: Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology. Eur Urol 2012;61:258-268.
16.
Lee S, Jeon HG, Kwak C, et al: Gender-specific clinicopathological features and survival in patients with renal cell carcinoma. BJU Int 2012;110:E28-E33.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.