Introduction: Our aim was to evaluate the clinical efficacy and safety of ureteroscopy as a primary treatment for pregnant women with symptomatic ureteric stones who have failed conservative management. Materials and Methods: A systematic review of the literature from January 1990 to June 2011 was performed, including all English language articles. Outcome measures were clinical efficacy, in terms of stone clearance and need for additional procedures, and safety in terms of complications. Results: A total of 239 abstracts were screened and 15 studies were identified reporting on 116 procedures. The surgical methods of stone management employed were stone extraction with basket only (n = 55, 47%), laser fragmentation (n = 27, 23%; holmium, n = 20, pulse dye, n = 7), impact lithotripsy (n = 21, 18%), ureteroscopic lithotripsy (n = 6, 5%) and a combination of methods (n = 6, 5%). A post-operative stent was inserted in 64 of 116 procedures (55%). Complete stone clearance was seen in 100 of the 116 procedures (86%). There were 2 major complications (1 ureteral perforation and 1 case of premature uterine contraction) and 7 minor complications (5 urinary tract infections and 2 cases of post-operative pain). Conclusion: This review suggests that stone clearance using ureteroscopy is a relatively safe option in pregnancy with a high success rate.

1.
Gorton E, Whitfield H: Renal calculi in pregnancy. Br J Urol 1997;80(suppl 1):4–9.
2.
Rodriguez PN, Klein AS: Management of urolithiasis in pregnancy. Surg Gynecol Obstet 1988;166:103–106.
3.
Drago JR, Rohner TJ, Chez RA: Management of urinary calculi in pregnancy. Urology 1982;20:578–581.
4.
Maikranz P, Coe FL, Parks JH, Lindheimer MD: Nephrolithiasis and gestation. Baillieres Clin Obstet Gynaecol 1987;1:909–919.
5.
Maikranz P, Lindheimer M, Coe F: Nephrolithiasis in pregnancy. Baillieres Clin Obstet Gynaecol 1994;8:375–386.
6.
Loughlin KR: Management of urologic problems during pregnancy. Urology 1994;44:159–169.
7.
Biyani CS, Joyce AD: Urolithiasis in pregnancy. I. Pathophysiology, fetal considerations, and diagnosis. BJU Int 2002;89:811–818.
8.
Kroovand RL: Stones in pregnancy; in Coe FL, Favus MJ, Pak CYC, Parks JH, Preminger GM (eds): Kidney Stones: Medical and Surgical Management. Philadelphia, Lippincott-Raven, 1996, pp 1059–1064.
9.
Lu Z, Dong Z, Ding H, Wang H, Ma B, Wang Z: Tamsulosin for ureteral stones: a systematic review and meta-analysis of a randomized controlled trial. Urol Int 2012;89:107–115.
10.
Hendricks SK, Ross SO, Krieger JN: An algorithm for diagnosis and therapy of management and complications of urolithiasis during pregnancy. Surg Gynecol Obstet 1991;172:49–54.
11.
Swartz MA, Lydon-Rochelle MT, Simmon D, Wright JL, Porter MP: Admission for nephrolithiasis in pregnancy and risk of adverse birth outcomes. Obstet Gynecol 2007;109:1099–1104.
12.
Boridy IC, Maklad N, Sandler CM: Suspected urolithiasis in pregnant women: imaging algorithm and literature review. AJR Am J Roentgenol 1996;167:869–875.
13.
McAleer SJ, Loughlin KR: Nephrolithasis and pregnancy. Curr Opin Urol 2004;14:123–127.
14.
Khoo L, Anson K, Patel U: Success and short-term complication rates of percutaneous nephrostomy during pregnancy. J Vasc Interv Radiol 2004;15:1469–1473.
15.
Türk C, Knoll T, Petrik A, et al: Guidelines on Urolithiasis. European Association of Urology, 2011.
16.
Scarpa RM, De Lisa A, Usai E: Diagnosis and treatment of ureteral calculi during pregnancy with rigid ureteroscopes. J Urol 1996;155:875–877.
17.
Carringer M, Swartz R, Johansson JE: Management of ureteric calculi during pregnancy by ureteroscopy and laser lithotripsy. Br J Urol 1996;77:17–20.
18.
Ulvik NM, Bakke A, Høisaeter PA: Ureteroscopy in pregnancy. J Urol 1995;154:1660–1663.
19.
Juan YS, Wu WJ, Chuang SM, Wang CJ, Shen JT, Long CY, Huang CH: Management of symptomatic urolithiasis during pregnancy. Kaohsiung J Med Sci 2007;23:241–246.
20.
Akpinar H, Tüfek I, Alici B, Kural AR: Ureteroscopy and holmium laser lithotripsy in pregnancy: stents must be used postoperatively. J Endourol 2006;20:107–110.
21.
Yang CH, Chan PH, La SK, Chang HC, Chiu B, Lin HM, Sheu MH: Urolithiasis in pregnancy. J Chin Med Assoc 2004;67:625–628.
22.
Lemos GC, El Hayek OR, Apezzato M: Rigid ureteroscopy for diagnosis and treatment of ureteral calculi during pregnancy. Int Braz J Urol 2002;28:311–315; discussion 316.
23.
Lifshitz DA, Lingeman JE: Ureteroscopy as a first-line intervention for ureteral calculi in pregnancy. J Endourol 2002;16:19–22.
24.
Watterson JD, Girvan AR, Beiko DT, Nott L, Wollin TA, Razvi H, Denstedt JD: Ureteroscopy and holmium:YAG laser lithotripsy: an emerging definitive management strategy for symptomatic ureteral calculi in pregnancy. Urology 2002;60:383–387.
25.
Shokeir AA, Mutabagani H: Rigid ureteroscopy in pregnant women. Br J Urol 1998; 81:678–681.
26.
Parulkar BG, Hopkins TB, Wollin MR, Howard PJ Jr, Lal A: Renal colic during pregnancy: a case for conservative treatment. J Urol 1998;159:365–368.
27.
Denstedt JD, Razvi H: Management of urinary calculi during pregnancy. J Urol 1992; 148:1072–1074; discussion 1074–1075.
28.
Rana AM, Aquil S, Khawaja AM: Semirigid ureteroscopy and pneumatic lithotripsy as definitive management of obstructive ureteral calculi during pregnancy. Urology 2009;73:964–967.
29.
Travassos M, Amselem I, Filho NS, Miguel M, Sakai A, Consolmagno H, Nogueira M, Fugita O: Ureteroscopy in pregnant women for ureteral stone. J Endourol 2009;23:405–407.
30.
Cocuzza M, Colombo JR Jr, Lopes RI, Piovesan AC, Borges Mesquita JL, Srougi M: Use of inverted fluoroscope’s C-arm during endoscopic treatment of urinary tract obstruction in pregnancy: a practicable solution to cut radiation. Urology 2010;75:1505–1508.
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