Aims: The purpose of this study was to investigate the prognostic significance of pigment epithelium-derived factor (PEDF) in human clear cell renal cell carcinoma (CCRCC) tissues. Patients and Methods: We investigated the expression of PEDF and its correlation with clinicopathological features in 203 patients who underwent radical nephrectomy for CCRCC. Expression of PEDF and CD34-positive vessels (microvessel density, MVD) in tumor samples was examined by immunohistochemistry. The relationship between PEDF expression and clinicopathologic features including tumor diameter, MVD, and survival was evaluated by univariate and multivariate analyses. Results: Of 203 patients, 116 cases (57.1%) were positive for PEDF. A significant association was found between PEDF expression and high MVD (p = 0.012). PEDF expression was inversely correlated with grade (p = 0.004) and pT stage (p = 0.001). Multivariate analysis using the Cox regression model indicated that PEDF expression was an independent favorable prognostic factor (risk ratio, 4.105; p = 0.001). However, no significant correlation was found between PEDF expression and age, gender, tumor diameter or lymph node invasion. Conclusion: Our findings suggest that PEDF may be a favorable prognostic indicator in patients with CCRCC.

Keywords:
Pigment epithelium-derived factor, Renal cell carcinoma, Angiogenesis
This content is only available via PDF.
© 2010 S. Karger AG, Basel
2010
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.