Rectal injuries diagnosed during radical prostatectomy are readily treated with primary closure and omental interposition. However, once this fails and a fistula develops, the treatment gets more complex. Various surgeries have been described to manage these fistulae, but these are not done frequently and require a great deal of expertise. We report a patient with post-radical prostatectomy rectourethral fistula, treated with cyanoacrylate glue injected through a colonoscope as the fistulous tract was well visualized per rectum. The patient is voiding well per urethra with no rectal leakage 3 months post-catheter removal. Thus, use of cyanoacrylate glue as a minimally invasive non-surgical technique for management of rectourethral fistula appears to be a good option which can be tried before embarking on major surgery.

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