Objective: This study aimed at comparing the urinary protein levels in calcium stone formers with those of healthy individuals. Patients and Methods: From January 2002 until June 2004, 100 calcium stone formers (mean age 38.6 ± 10.3 years), who had at least two episodes of calcium stone formation, were compared with 100 healthy individuals (mean age 33.8 ± 9.7 years). Their 24-hour urinary protein levels, using SDS-PAGE, were measured. Results: The mean 24-hour urinary Tamm-Horsfall protein (THP) levels were 3.3 ± 0.8 mg in the case group and 4.6 ± 1.9 mg in the controls, and the difference was not statistically significant (p = 0.53). However, the THP levels in individuals with and without bacteriuria were significantly different (15.8 ± 3.3 mg vs. 2.6 ± 1.0 mg, p = 0.0001). The mean 24-hour urinary albumin concentrations were 163.31 ± 15.1 mg in the case group and 74.26 ± 4.6 mg in the controls. The mean 24-hour urinary transferrin levels were 8.09 ± 2.7 mg in the case group and 0.40 ± 0.3 mg in the controls. The differences were statistically significant for both albumin and transferrin (p < 0.0001 and p = 0.0063, respectively). There were no significant differences in any other mean urinary protein concentrations between cases and controls. Conclusions: The THP level in the urine of stone formers is not quantitatively different from that of healthy individuals, but it increases in association with bacteriuria. Albumin and transferrin may play a presumptive role in stone formation.

Keywords:
Calcium stone formation, Tamm-Horsfall protein, Albumin, Transferrin, Bacteriuria
This content is only available via PDF.
© 2006 S. Karger AG, Basel
2006
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.