Background: The principle of treating male infertility in those with chromosomal aberrations should change according to progress in treatment modalities. Methods: In this study, ten patients with Robertsonian translocation were assessed for their cytogenetic and clinical characteristics to establish guidelines for treating these patients. Results: In 8 of 10 cases, chromosomes 13 and 14 were involved. In 4 of 10 cases (40%), their wives became pregnant, including two spontaneously. All newborns were without any deformities including one boy who was shown to have a normal karyotype. Conclusion: Infertility treatment of patients with Robertsonian translocation should be optimistically performed on the basis of proper informed consent.

Keywords:
Robertsonian translocation, Male infertility, Oligozoospermia, Pregnancy, Genetic counseling
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© 2002 S. Karger AG, Basel
2002
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