We report on a 69 year-old patient with a leiomyoma of the seminal vesicle who presented with dysuria and pollakiuria. The rectal examination revealed a large, hard mass in an area corresponding to the seminal vesicle. The prostate was suspicious of malignancy, but transrectal needle biopsy specimens were negative. We managed the patient by prostatovesiculectomy. The pathological findings and the immunohistochemical staining pattern of smooth muscle with antibodies against β-actin and desmin confirmed the diagnosis of a leiomyoma of the left seminal vesicle. To our knowledge, this kind of tumour is exceedingly rare, with only a few cases reported in the literature.

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