The ability of three compounds, all similar in chemical structure to citric acid, to decrease calcium crystalluria has been measured. The measurements were made in normal human urine at 37 ° C and compared with the crystal-decreasing power of citric acid when measured in the same way and in the same urine samples. One of the compounds tested, phosphocitric acid, was more potent than citric acid in inhibiting calcium oxalate crystal precipitation. At higher concentrations it also proved more effective against calcium phosphate. A urine evaporation method was used to carry out the crystal inhibition tests after modification to improve its precision.

Keywords:
Urinary stone, Crystalluria, Crystal inhibition measurement, Crystal inhibitors, Citric acid analogues
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© 1996 S. Karger AG, Basel
1996
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