Five patients with a second penile cancer following irradiation of a primary squamous cell carcinoma of the penis were treated at our center. The first cancers had completely regressed within 4 months of irradiation. The second cancers developed in the radiation field at a mean latent period of 158 months (range 124–242). Further, all patients had experienced early radiation reaction and showed late radiation stigmata, pointing to the possible radiation-induced nature of the second cancer. Although all cancers were squamous cell carcinomas, the second cancers were uniformly invasive and of a higher grade than the first. Radiation-induced second cancers, although rare, should be considered a late complication of primary irradiation of squamous cell carcinoma of the penis.

Keywords:
Penile neoplasms, Carcinoma, squamous cell, Radiation therapy, Second primary cancer
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© 1995 S. Karger AG, Basel
1995
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