In order to study the segmental difference in the density of autonomic receptors of the vas deferens, we measured the amount of adrenergic α1-, α2- and β-receptors and muscarinic cholinergic receptors in the three portions (prostatic, intermediate and epididymal) of dog vas deferens using radioligand binding techniques. Saturation experiments with 3H-prazosin, 3H-yohimbine, 3H-dihydroxyalprenolol and 3H-quinuclidinyl benzilate demonstrated that three were significant amounts of adrenergic α1-, α2- and β-receptors and muscarinic cholinergic receptors in the three portions of dog vas deferens. Of the three portions examined, the prostatic portion was found to have a larger amount of α1-, α2-receptors and muscarinic receptors, while the intermediate portion was found to have a larger amount of β-receptors. The epididymal portion was found to have a smaller amount of autonomic receptors. These data suggest that the prostatic portion plays a more important role in the function of the dog vas deferens. It is thought that the different segments of the vas deferens have a different functional role according to the distribution of autonomic receptors.

Keywords:
α1-Receptor, α2-Receptor, β-Receptor, Muscarinic cholinergic receptor, Vas deferens, dog, Segmental difference
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© 1994 S. Karger AG, Basel
1994
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