The purpose of the present study was to examine the effect of the Α2-adrenoceptor antagonists yohimbine and idazoxan on kidney function in intact Sprague-Dawley rats and in Brattleboro rats with familial hypothalamic diabetes insipidus. Both drugs, injected intravenously at 0.5 mg/kg, led to a marked decrease of urine flow, sodium, potassium and chloride excretion in both strains of rats. Glomerular filtration rate and effective renal plasma flow did not change significantly in either strain. The study demonstrates that the Α2-adrenoceptor antagonists induce an antidiuretic effect without changes in renal hemodynamics. Antidiuretic hormone does not play a role in yohimbine- or idazoxan-induced antidiuresis. The data suggest a role for Α2-adrenoceptors in the renal tubular handling of water and salt.

Keywords:
Kidney function, Rats, Yohimbine, Idazoxan, α2-Adrenoceptors
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© 1989 S. Karger AG, Basel
1989
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