Partial obstruction of the left ureter was created in rats less than 36 h of age and its effects were studied at the age of 2–6 days. A considerable hydronephrosis with distension of the kidney developed within 1 day after obstruction, but there was no parenchymal weight reduction. The thickness of the mature, inner cortical layer was significantly decreased, suggesting a delay in the differention of the cortex. The parenchymal weight reduction, previously documented in our laboratory after long-standing ureteric obstruction, may thus be caused by a retardation of renal growth, which is never caught up, rather than by an atrophy of renal parenchyma or other destructive tissue lesions.

Keywords:
Hydronephrosis, experimental Morphology, Newborn rats, Partial ureteric obstruction, Nephrons, immature
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© 1989 S. Karger AG, Basel
1989
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