Contractile responses of urinary bladder muscle strips to prostaglandin (PG) E1, E2 and F2α were compared in young and old rabbits. All PGs tested caused an increase in contractile force of urinary bladder muscle strips from young (3 weeks) and old ( > 2 years) rabbits. The contractile response was most marked with PGE2 at concentrations of 10––10––10–7M in muscle strips from both young and old rabbits. At a high concentration (10––5M), the contractile response was most marked with PGF2α in young rabbit bladder muscle strips, whereas in old rabbit bladder muscle strips the magnitude of the responses to PGE2 and PGF2α were equal at 10––6M and both were greater than the response to PGE1. The contractile response to PGE1 was greater in old detrusor than in young detrusor at concentrations ≧ 10––6M, whereas the contractile response to PGE2 (10––7––10––5M) and PGF2α (10––6––10––5M) were greater in young detrusor than in old detrusor. These data show that rabbit detrusor muscle shows a contractile response to PGE1, E2 and F2α and that the magnitude of these responses vary with age.

Keywords:
Detrusor muscle contraction, Prostaglandins, Age dependence
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© 1987 S. Karger AG, Basel
1987
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