Effects of prostaglandins (PGs) E1; E2 and F2Α on the vesical and urethral smooth muscles of dogs were isometrically investigated in vitro. In vesical smooth muscles, 10––8–10––6 g PGE1/ml produced biphasic responses in the dome preparations; relaxation at 10––8 g/ml and contractions at 10––7–10––6 g/ml. In the trigone preparations, 10––8–10––6 g PGE1/ml caused dose-dependent contractions. 10––8–10––6 g PGE2/ml and 10––7–10––6 g PGF2Α/ml induced dose-dependent contractions of the dome and the trigone preparations. In urethral smooth muscles, 10––8–10––6 g PGE1/ml and 10––8–10––6 g PGE2/ml produced dose-dependent relaxations, while 10––8–10––6 g PGF2Α/ml caused dose-dependent contractions. Results indicate that PGE, particularly PGE2, is able to stimulate micturition through vesical contraction and urethral relaxation.

Keywords:
Isolated dog urinary bladder and urethra, Prostaglandins, Basal tone, Contraction, Relaxation
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© 1983 S. Karger AG, Basel
1983
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