Urinary amino acid excretion levels were estimated by paper chromatography in 15 control subjects and 27 stone formers classified according to stone type: (a) 15 cases with calcium oxalate stones, either pure or mixed with calcium phosphate and/or uric acid; (b) 6 cases with pure uric acid stones and (c) 6 cases with magnesium-ammonium phosphate stones, either pure or mixed with ammonium urate, also the free amino acid contents of the calculi of different types were estimated. The data revealed that there was a significant decrease in the amino acid excretion in all stone formers; the individual amino acid patterns varied according to the type of stone formed. This decrement in amino acid excretion could be attributed to: (a) a metabolic defect in the pathway of glycine, especially in the calcium oxalate cases; (b) the precipitation and/or adsorption of the free amino acids on the material of the calculi, which is demonstrated in 10 calculi, and (c) to a lesser extent to bacterial infection.

Keywords:
Amino Acids, Urolithiasis, Calculus
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© 1983 S. Karger AG, Basel
1983
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