The gradient of cellular [Na+] on [K+] ion within the renal pelvis of the rabbit was correlated with the autorhythmicity of the proximal, middle, distal and ureteropelvic regions of this structure. The results show that the maximum frequency of spontaneous pacemaker contractions occur at the proximal pelvis with a mean frequency of 4.97 ± 0.85 contractions/min, a mean [Na+] of 91.0 ± 33.3 mEq/kg wet weight, a mean [K+] of 18.9 ± 6.0 mEq/kg wet weight. The frequency of spontaneous activity from the middle pelvis and distal pelvis decreases to mean values of 2.76 ± 0.60 and 1.82 ± 0.56 contractions/min. The corresponding values for [Na+] and [K+] are 78.0 ± 27.7 and 11.8 ± 4.7 for the middle pelvis and 66.6 ± 32.7 and 9.75 ± 3.4 for the distal pelvis, respectively. Normalized regression curves indicate a [Na+] gradient variation of Δ [Na+] = 67.1 ± 0.07Δ F and a [K+] gradient of Δ [K+] = 39.8 –– 0.06Δ F + 0.01 Δ F2. Spatially, the variation of [Na+] and [K+] with distance, D, within the pelvis is given by [Na+] = 119 –– 14D + D2 and [K+] = 26 –– 11D + 2D2. It is concluded from this study that there is a frequency gradient between proximal renal pelvis and ureteropelvic junction which is significantly interdependent upon the cellular [Na+] on [K+] concentration gradient.

Keywords:
Renal pelvis, Pacemaker, Rabbit
This content is only available via PDF.
© 1981 S. Karger AG, Basel
1981
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.