In 34 dogs the effect of a 90-min period of warm ischemia on renal perfusion and function was studied with and without (Sar1, He8) angiotensin II treatment. In the first 3 h after the release of renal arterial occlusion, a significant influence of the angiotensin II antagonist on changes in postischemic vascular resistance, intrarenal hemodynamics and renal function could be demonstrated, all being well preserved in the treated group.

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