Renal scintigraphy with 99mTc-dimercaptosuccinic acid (DMSA) was used to determine the prognosis of patients with adult polycystic kidney disease. In 40 patients, DMSA renal uptake rate, serum creatinine and blood urea nitrogen (BUN) were examined in different periods, at least twice a year. These parameters were plotted on semilogarithmic paper against the course of observation period (years or months in duration). As the impairment of renal function progresses, these parameters gradually worsen, DMSA renal uptake decreases and serum creatinine and BUN elevate linearly. In the terminal stage when hemodialysis is required, total DMSA uptake decreased to less than 1%, and this paralleled the levels of 100 mg/dl of BUN and 10 mg/dl of serum creatinine. Accordingly, when linear lines of parameters are extended to those levels obtained in hemodialysis patients, the years and months which coincide on the abscissa can be accounted for when initiation of the hemodialysis is taken into consideration. Analysis of this linear relation in individual patients allows for an estimate of the progression of this disease and may assist in the determination of the effects of conservative treatment. This method also indicates that the level of DMSA uptake at the initial diagnosis is a critical factor in assessing the prognosis of the patient.

Keywords:
Polycystic kidney disease, 99mTc-DMSA renal scintigraphy, DMSA renal uptake, Hemodialysis
This content is only available via PDF.
© 1980 S. Karger AG, Basel
1980
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.