Abstract
Renal embolization was performed in 12 dogs using the Seldinger technique and microspheres 250 ± 40 µm in diameter. Periodical arteriography, microangiographies and histological analysis were carried out to control the efficacy of embolization. As a result, renal arteries could be embolized with microspheres, however, because of statistical distribution there were histologically anemic and normal parenchyma situated closely together. In more than 50% there was a reflux of microspheres which could only be detected by histological examination, while angiographies showed a totally normal vascular pattern. Microspheres should not be used in clinical embolization. Experimental investigation of embolization materials must almost embrace histological analysis.