By elution chromatography using ion exchange resin, Amberlite IRC-50, the urinary 17-KS and 17-OHCS were fractionated in 16 adult patients with Cushing’s syndrome, and were compared to those in 17 normal subjects. It was shown in all patients with Cushing’s syndrome that ratios of 5β-H-steroids to 5α-H-steroids, that is, THF to allo-THF and etiocholanolone to androsterone, were above the normal range, in company with increased excretion of total 17-OHCS. Differences of excretion patterns among the three types of Cushing’s syndrome were as follows. In a case of adrenal carcinoma, the highest and markedly elevated amounts of THS, DHA, 17-OHCS and 17-KS were excreted. In 8 of 9 patients with adenoma, ratios of etiocholanolone + androsterone to 11-oxy-17-KS were below the lower limit found in 6 patients with hyperplasia, while the ratios were below the normal range in all patients with adenoma.

Keywords:
Cushing’s syndrome, 17-KS, Fractionation, 17-OHCS, Fractionation
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© 1974 S. Karger AG, Basel
1974
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