The guinea pig seminal vesicle sac preparation is described. The uptake, distribution and secretion of 3–0-methylglucose (3mG), α-amino-isobutyric acid (AIB), testosterone (T) and adenosine (A) were examined following the addition of these substances to the serosal fluid. The findings suggest that AIB is actively transported into the cells of the sex accessory tissues while 3mG enters by the process of simple diffusion. In addition, 3mG readily penetrated into the mucosal fluid, achieving a concentration of approximately one half that detected in the tissue. The uptake and metabolism of testosterone-3H occurred in both the epithelial and muscular layer. Only small amounts of androgen were detected in the mucosal fluid (lumen). Adenosine-3H was detected in near equal concentrations in the epithelial and muscular layers. Little adenosine-3H reached the lumen of the vesicular model. The in vitro bioconversion of adenosine-3H to cAMP-3H revealed equal distribution of this cyclic nucleotide in the epithelial and muscular layers of the seminal vesicle. Substantial amounts of cAMP-3H were found in the lumen of the in vitro preparation.

Keywords:
Seminal vesicle transport processes, Seminal vesicle sac, Vesicular model, Vesicular constituents, cAMP-3H and seminal vesicles, Non-utilizable hexoses, Non-utilizable amino acids
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© 1974 S. Karger AG, Basel
1974
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