In order to study the survival time of transplants in closely related species, kidney of cats were transplanted into mongrel dogs using an ‘en bloc technique’. A delayed type of hyperacute xenogeneic rejection was found. Beginning of rejection at an early stage was indicated by a decrease of serum complement during the first 6 h. At the same time cat protein and considerable amounts of potassium were found in urine samples. Though there was good evidence for severe damage of the transplanted organs, complete loss of function could not be ascertained for up to 15–24 h. The end stage of the antigen-antibody reaction is characterized by an increase of complement values towards normal. Final rejection of the transplant is probably due to nonspecific mechanism.

Keywords:
Xenografting, Kidney transplantation, ‘en bloque technique’, Closely related species
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© 1973 S. Karger AG, Basel
1973
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