Renal vasospasm occurring during the agonal phase of many cadaver donors can influence the success of renal homotransplantation because this spasm can persist after nephrectomy and even transplantation. It is of great importance to prevent or to relieve this vasospasm. In dog experiments the vasodilatative effect of 2% novocain, papaverine hydrochloride and phenoxybenzamine was examined performing angiograms. Vasospasm, induced by hemorrhagic shock, could fairly be influenced by the application of novocain. Papaverine hydrochloride and phenoxybenzamine showed a minor vasodilatative effect in the isolated vasospastic kidney. The preventive effect of phenoxybenzamine, given before the beginning of shock, justifies the application of this substance to all cadaver donors to prevent vasospasm.

Keywords:
Vasospasm in shock, Pretreatment of cadaver donors, Phenoxybenzamine and shock, Drugs in shock, Vasospasm in donor kidneys, Treatment of vasospasm, Vasospasm in the isolated kidney, Renal vasospasm in shock, Angiograms of shock kidneys
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© 1973 S. Karger AG, Basel
1973
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