The diagnostic value of a urinary enzyme pattern following renal ischaemia, intoxication or pyelonephritis was examined in rabbits. After carefully, selecting elements of the enzyme pattern we observed, besides a general increase of activity of all elements, an important shift of proportions of single element activities within the assayed enzyme pattern, permitting the diagnosis of the experimental renal damage. In this way we investigated renal reaction following ischaemia. We regarded the extent of shift of the proportions and the sequence of the elements within the enzyme pattern: (1) within wide limits the healthy kidney shows a similar reaction following hypoxia of various periods; (2) a toxically predamaged kidney demonstrates this reaction up to a maximum of 15 min; after each further hypoxia there is no longer predictable reaction of the kidney.

Keywords:
Urinary enzyme pattern, Diagnosis of renal ischaemia, intoxication or pyelonephritis
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© 1973 S. Karger AG, Basel
1973
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