3H-Thymidinautoradiographic studies were carried out on the hyperplastic and metaplastic changes of urinary tract epithelium in the human bladder and after their experimental induction in the rat bladder. The following findings were established: 1. Considerably increased cellular proliferation is recognized in hyperplastic changes. 2. Following foreign body irritation of the animal bladder, hyperregeneration remains limited to the basal cell layers. 3. Study of biopsied human urinary tract epithelium from patients with chronic inflammatory and proliferative mucous membrane changes demonstrated, in some of the cases, a loss of physiologic growth-regulation (as seen in dividing cells in the intermediate and superficial cellular layers outside the regeneration-zone), as may be established experimentally in the early stages of the cancerous process. The significance of these findings for the early comprehension of the malignant potency of facultative precancerous states of the urinary bladder is discussed.

Keywords:
Praecancerous changes, Urinary bladder, 3H-Thymidinautoradiography
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© 1972 S. Karger AG, Basel
1972
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