Perineal puncture procured material from 10 patients with clinically and microscopically proven prostatic cancer, both before and after intensive female-hormonal therapy and after castration; the tissues were studied histochemically and microscopically. Apart from tissue acid-phosphatase, the following were investigated: succino-dehydrogenase (SDH), isocitrate-dehydrogenase (LCDH), β-hydroxybutyrate-dehydrogenase (β-BDH), glucose-6-phosphate-dehydrogenase (G-6-PDH), glutamate-dehydrogenase (GDH), lactate-dehydrogenase (LDH). Following hormonal therapy and castration there was, in both the solid cancer and in adenocarcinoma, a readily demonstrable fall of enzymatic activity compared to that at initial puncture. Striking was the transition to dedifferentiation of the adenocarcinoma following hormonal therapy and castration despite improvement in clinical palpation. In the presence of negative stromal reaction, the tumor cells of the dedifferentiated cancer there was obvious activity of the GDH, LDH, β-BDH and acid phosphatase. There was slight to no activity of citrate and pentose-phosphate cycle. Two patients with histologically dedifferentiated carcinoma and adenocarcinoma, respectively, after second puncture, showed no evidence of cancerous tissues while at the same time evincing limitation of enzymatic activity (LDH) to the smooth muscle.

Keywords:
Human prostate, Cancer, Therapy (castration, estrogen, Cytonal), Enzyme histochemistry
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© 1971 S. Karger AG, Basel
1971
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