A simplified and standardized pre- and postoperative treatment technique for Cushing’s syndrome and pheochromocytoma was discussed from experiences on 21 and 18 cases, respectively, treated in our clinic since 1956. Results were summarized as follows: Cushing’s syndrome: A subtotal adrenalectomy with pre- and postoperative irradiation to the hypophysis by a large dosis of telecobalt was effective for the cases with bilateral adrenal hyperplasia. A standard program of postoperative substitution therapy, which was composed of minimized cortisol supplement without ACTH administration, was described. Pheochromocytoma: Three methods presented for blood pressure control after the removal of pheochromocytoma, i.e., noradrenaline drip method, blood overtransfusion method, and the treatment with receptor blocking drugs, were evaluated. Results of the hemodynamic determinations in the pre- and postoperative period were demonstrated. The most reliable management might be obtained from a combined technique with overtransfusion and receptor blockers.

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