In 7 patients undergoing general anesthesia and transurethral resection of the prostate, the effective renal plasma flow (ERPF) was recorded before, during and after anesthesia using a new isotope feedback technique. The isotope we used was I131 iodopyracet. In comparison to the average preanesthetic I131 iodopyracet clearance (319 ml/min), the clearance measurements during general anesthesia in 7 patients revealed a fall in ERPF of 32%. In 5 of these patients receiving pentothal-N2O-oxygen anesthesia there was a decrease of renal plasma flow of 30%. Epidural anesthesia was attempted in the remaining two patients but proved to be insufficient. One of these patients received nitrous oxide-oxygen anesthesia which caused a fall in ERPF of 31%. To the second patient halothane-N2O-oxygen anesthesia was given, which was followed by a decrease in renal plasma flow of 44%. A more detailed study revealed a fall of 29% in iodopyracet clearance during general anesthesia before operation and a fall of 35% during transurethral prostatectomy. After general anesthesia we found in all patients a marked increase of renal plasma flow.

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© 1970 S. Karger AG, Basel
1970
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