Mannitol administration and therapeutic dénervation of the kidney were combined in post-ischaemic experiments. Ischaemic shock was brought about by transitory clamping of the renal artery. Hibernation combined with mannitol administration was the most effective therapeutic measure (others were mannitol only, hibernation only, novocain, novocain+mannitol) in renal failure. This was attributed to the inhibitory effect of hibernation upon vasoconstrictive impulses coming by way of the preglomerular ateries, thus facilitating the intrarenal action of mannitol. Hydropic degeneration, a side effect of mannitol, was found to be a transitory lesion not affecting renal function very much.

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© 1969 S. Karger AG, Basel
1969
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