In previous work it was shown that urine contains a compound inhibiting calcium phosphate and calcium oxalate precipitation in vitro. This inhibitor was identified as inorganic pyrophosphate. The urinary excretion of pyrosphosphate was found to be increased by oral administration of orthophosphate, a procedure claimed to prevent urolithiasis. In this study the possible influence of pyrophosphate on the crystallisation of uric acid and magnesium ammonium phosphate has been examined in vitro. Pyrophosphate, at a concentration of 5 × 10––5 M, equivalent to that found in normal urine, had no effect on the precipitation of either of these compounds under the experimental conditions employed. It is therefore concluded that if orthophosphate administration acts therapeutically only by increasing urinary pyrophosphate it is unlikely to be effective against stones composed of uric acid or magnesium ammonium phosphate. The use of orthophosphate therapy against other types of stones is discussed.

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© 1967 S. Karger AG, Basel
1967
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