The concentration of ampicillin in prostatic fluid, prostatic tissue, blood and urine was determined in different groups of patients and dogs using bioassays. The concentration found in prostatic fluid was as high as that of blood and in patients with chronic prostatitis slightly higher. It is shown that this is probably due to contamination of prostatic fluid with urine, even if care had been taken to minimize this possibility. The importance of considering this factor in similar experiments is stressed. Only insignificant amounts of ampicillin were found in prostatic tissue removed at open prostatic surgery. Ampicillin was not found in therapeutic concentration in prostatic fluid of a patient with ureterosigmoidostomy and of dogs in which a prostatic fistula previously had been made. It is concluded that ampicillin is not found in prostatic tissue and prostatic fluid in therapeutic concentrations and therefore doubtful whether ampicillin will benefit patients with chronic prostatitis.

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© 1967 S. Karger AG, Basel
1967
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