The determination was carried out with colorimetric methods of 3-indol-acetic acid (IAA) and 5-hydroxy-indolacetic acid (5HIAA) in the urine of patients suffering from vesical neoplasia and control subjects before and after load with tryptophan. No difference was noted in the elimination of 5HIAA in the two groups. On the other hand, it was found that the subjects with vesical neoplasia eliminate, on an average, a larger quantity of IAA in the urine, in particular, in these patients the elimination of the conjugated amount of IAA appears increased, so that the ratio free IAA/ conjugated IAA diminishes. After dosing with tryptophan, there are no changes in the elimination of 5HIAA in either of the two groups, while there is a marked increase in the elimination of IAA in all the patient. After dose also the free IAA/conjugated IAA ratio is smaller in the subjects with vesical neoplasia. Finally, for two subjects of the latter group, the values of the elimination of IAA before and after dose are considerably different from the average figures.

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© 1965 S. Karger AG, Basel
1965
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